How heterogeneity in glucokinase and gap junction coupling determines the islet electrical response
J. M. Dwulet, N. Ludin, R. A. Piscopio, W. E. Schleicher, O. Moua, M. Westacott, R. K. Benninger
The paper shows that electrical coupling enables a minority of glucose-metabolizing β-cells to drive islet-wide calcium responses, but insufficient numbers or disrupted coupling suppresses these responses.
bioRxiv · Jul 8, 2019Biophysics