Author

R. A. Piscopio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:electrophysiology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

R. K. Benninger· 3 shared J. M. Dwulet· 2 shared W. E. Schleicher· 2 shared A. M. Davis· 1 shared C. G. Johansen· 1 shared D. J. Hodson· 1 shared J. Collins· 1 shared L. Pyle· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

R. K. Benninger

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3 papers

Recent·Most cited

Cleavage of protein kinase c δ by caspase-3 mediates pro-inflammatory cytokine-induced apoptosis in pancreatic islets

J. Collins, R. A. Piscopio, M. E. Reyland, C. G. Johansen, R. K. Benninger, N. L. Farnsworth

This study identifies PKCδ's role in cytokine-induced apoptosis in pancreatic β-cells, showing that caspase-3 cleavage and nuclear translocation of PKCδ are required for cytokine-mediated β-cell death.

Journal of Biological Chemistry · Sep 1, 2024Peer-reviewedCell Biology

Functional architecture of the pancreatic islets: First responder cells drive the first-phase response

V. Kravets, J. M. Dwulet, W. E. Schleicher, D. J. Hodson, A. M. Davis, L. Pyle, R. A. Piscopio, M. Sticco-Ivins, R. K. Benninger

The paper identifies and characterizes first responder beta-cells in pancreatic islets that drive the first-phase calcium response to glucose.

bioRxiv · Dec 22, 2020Biophysics

How heterogeneity in glucokinase and gap junction coupling determines the islet electrical response

J. M. Dwulet, N. Ludin, R. A. Piscopio, W. E. Schleicher, O. Moua, M. Westacott, R. K. Benninger

The paper shows that electrical coupling enables a minority of glucose-metabolizing β-cells to drive islet-wide calcium responses, but insufficient numbers or disrupted coupling suppresses these responses.

bioRxiv · Jul 8, 2019Biophysics