Author

J. M. Dwulet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 5 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 3 Assay:electrophysiology· 3 Approach:statistical model· 3 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

R. K. Benninger· 6 shared V. Kravets· 4 shared W. E. Schleicher· 4 shared J. G. Miranda· 2 shared J. K. Briggs· 2 shared N. L. Farnsworth· 2 shared R. A. Piscopio· 2 shared A. Heintz· 1 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersBiophysics

R. K. Benninger

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Beta-cell Metabolic Activity Rather than Gap Junction Structure Dictates Subpopulations in theIslet Functional Network

J. K. Briggs, V. Kravets, J. M. Dwulet, D. J. Albers, R. K. Benninger

The paper shows that metabolic activity, not gap junction structure, determines beta-cell subpopulations in the islet functional network.

bioRxiv · Feb 6, 2022Biophysics

Functional architecture of the pancreatic islets: First responder cells drive the first-phase response

V. Kravets, J. M. Dwulet, W. E. Schleicher, D. J. Hodson, A. M. Davis, L. Pyle, R. A. Piscopio, M. Sticco-Ivins, R. K. Benninger

The paper identifies and characterizes first responder beta-cells in pancreatic islets that drive the first-phase calcium response to glucose.

bioRxiv · Dec 22, 2020Biophysics

RESTORING CONNEXIN-36 FUNCTION IN DIABETOGENIC ENVIRONMENTS PRECLUDES MOUSE AND HUMAN ISLET DYSFUNCTION

J. R. St Clair, M. J. Westacott, J. G. Miranda, N. L. Farnsworth, V. Kravets, W. E. Schleicher, J. M. Dwulet, C. H. Levitt, A. Heintz, N. W. F. Ludin, R. K. Benninger

This study shows that restoring Cx36 gap junction function in diabetic conditions improves islet function in both mice and humans.

bioRxiv · Nov 3, 2020Biophysics

Small subpopulations of β-cells do not drive islet oscillatory dynamics via gap junction communication

J. M. Dwulet, J. K. Briggs, R. K. Benninger

This study shows that small subpopulations of β-cells cannot disproportionately control islet-wide [Ca2+] oscillations via gap junction coupling, as removing them does not significantly alter islet function.

bioRxiv · Oct 28, 2020Biophysics

Caloric Restriction recovers impaired β-cell-β-cell coupling, calcium oscillation coordination and insulin secretion in prediabetic mice

M. E. C. do Amaral, V. Kravets, J. M. Dwulet, N. L. Farnsworth, R. Piscopio, W. E. Schleicher, J. G. Miranda, R. K. Benninger

This study shows caloric restriction improves β-cell coupling, calcium oscillations, and insulin secretion in prediabetic mice by restoring Cx36 gap junction function.

bioRxiv · Mar 3, 2020Physiology

How heterogeneity in glucokinase and gap junction coupling determines the islet electrical response

J. M. Dwulet, N. Ludin, R. A. Piscopio, W. E. Schleicher, O. Moua, M. Westacott, R. K. Benninger

The paper shows that electrical coupling enables a minority of glucose-metabolizing β-cells to drive islet-wide calcium responses, but insufficient numbers or disrupted coupling suppresses these responses.

bioRxiv · Jul 8, 2019Biophysics