Author

W. E. Schleicher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell signaling & trafficking· 4 Assay:electrophysiology· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

R. K. Benninger· 5 shared J. M. Dwulet· 4 shared J. G. Miranda· 3 shared V. Kravets· 3 shared N. L. Farnsworth· 2 shared R. A. Piscopio· 2 shared A. Heintz· 1 shared A. M. Davis· 1 shared

Activity by Year

2019-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersBiophysics

R. K. Benninger

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5 papers

Recent·Most cited

Functional architecture of the pancreatic islets: First responder cells drive the first-phase response

V. Kravets, J. M. Dwulet, W. E. Schleicher, D. J. Hodson, A. M. Davis, L. Pyle, R. A. Piscopio, M. Sticco-Ivins, R. K. Benninger

The paper identifies and characterizes first responder beta-cells in pancreatic islets that drive the first-phase calcium response to glucose.

bioRxiv · Dec 22, 2020Biophysics

RESTORING CONNEXIN-36 FUNCTION IN DIABETOGENIC ENVIRONMENTS PRECLUDES MOUSE AND HUMAN ISLET DYSFUNCTION

J. R. St Clair, M. J. Westacott, J. G. Miranda, N. L. Farnsworth, V. Kravets, W. E. Schleicher, J. M. Dwulet, C. H. Levitt, A. Heintz, N. W. F. Ludin, R. K. Benninger

This study shows that restoring Cx36 gap junction function in diabetic conditions improves islet function in both mice and humans.

bioRxiv · Nov 3, 2020Biophysics

Dynamic changes in β-cell electrical activity and regulates NFATc3 activation and downstream gene transcription

J. G. Miranda, W. E. Schleicher, D. G. Ramirez, S. P. Landgrave, R. K. Benninger

This study investigates how dynamic changes in β-cell electrical activity and calcium oscillations regulate NFAT activation and downstream gene transcription, showing impaired responses in type 2 diabetes.

bioRxiv · Jun 28, 2020 · PreprintBiophysics

Caloric Restriction recovers impaired β-cell-β-cell coupling, calcium oscillation coordination and insulin secretion in prediabetic mice

M. E. C. do Amaral, V. Kravets, J. M. Dwulet, N. L. Farnsworth, R. Piscopio, W. E. Schleicher, J. G. Miranda, R. K. Benninger

This study shows caloric restriction improves β-cell coupling, calcium oscillations, and insulin secretion in prediabetic mice by restoring Cx36 gap junction function.

bioRxiv · Mar 3, 2020Physiology

How heterogeneity in glucokinase and gap junction coupling determines the islet electrical response

J. M. Dwulet, N. Ludin, R. A. Piscopio, W. E. Schleicher, O. Moua, M. Westacott, R. K. Benninger

The paper shows that electrical coupling enables a minority of glucose-metabolizing β-cells to drive islet-wide calcium responses, but insufficient numbers or disrupted coupling suppresses these responses.

bioRxiv · Jul 8, 2019Biophysics