Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
E. W. Martin, F. E. Thomasen, N. M. Milkovic, M. J. Cuneo, C. R. Grace, A. Nourse, K. Lindorff-Larsen, T. Mittag
This study investigates how folded domains of hnRNPA1 modulate phase separation behavior of its disordered low-complexity domain, showing salt-dependent effects through electrostatic interactions and solubility changes.
bioRxiv · May 15, 2020Biophysics