Author

C. R. Grace

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

K. Lindorff-Larsen· 3 shared F. Pesce· 2 shared T. Mittag· 2 shared A. Bremer· 1 shared A. Nourse· 1 shared B. B. Kragelund· 1 shared C. G. Robinson· 1 shared C. O. Rock· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBiophysics

K. Lindorff-Larsen

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5 papers

Recent·Most cited

Design of intrinsically disordered protein variants with diverse structural properties

F. Pesce, A. Bremer, G. Tesei, J. B. Hopkins, C. R. Grace, T. Mittag, K. Lindorff-Larsen

This paper introduces a physics-based algorithm to design intrinsically disordered proteins with specified structural properties, demonstrating high accuracy in predicting compaction and phase separation behavior.

bioRxiv · Oct 22, 2023Biophysics

Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

F. Pesce, E. A. Newcombe, P. Seiffert, E. E. Tranchant, J. G. Olsen, C. R. Grace, B. B. Kragelund, K. Lindorff-Larsen

The paper evaluates models for calculating the hydrodynamic radius of intrinsically disordered proteins using conformational ensembles validated by small-angle X-ray scattering and finds the Kirkwood-Riseman equation to be the most accurate.

bioRxiv · Jun 11, 2022Biophysics

PPIX-binding Proteins Reveal Porphyrin Synthesis and Ferroptosis Link

J. Lynch, Y. Wang, Y. Li, K. Kavidia, Y. Fukuda, S. Ranjit, C. G. Robinson, C. R. Grace, Y. Xia, J. Peng, J. Schuetz

The paper identifies PPIX-binding proteins and shows that increased heme/porphyrin synthesis promotes ferroptosis distinct from canonical ferroptosis, with PRDX3 modulating this process.

bioRxiv · Jun 1, 2022 · PreprintBiochemistry

Structural transitions permitting ligand entry and exit in bacterial fatty acid binding proteins.

S. W. White, C. O. Rock, E. Tajkhorshid, J. M. Gullett, M. G. Cuypers, C. R. Grace, C. Subramanian, S. Pant

This study reveals how FakB1 transitions between closed and open states to facilitate fatty acid exchange with the membrane.

bioRxiv · Sep 16, 2021 · PreprintBiophysics

Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

E. W. Martin, F. E. Thomasen, N. M. Milkovic, M. J. Cuneo, C. R. Grace, A. Nourse, K. Lindorff-Larsen, T. Mittag

This study investigates how folded domains of hnRNPA1 modulate phase separation behavior of its disordered low-complexity domain, showing salt-dependent effects through electrostatic interactions and solubility changes.

bioRxiv · May 15, 2020Biophysics