Heat Shock Protein 27 versus Estrogen Therapy for Post-Menopausal Atherosclerosis: Rethinking Mechanisms of Cholesterol Lowering
N. Maarouf, Y.-X. Chen, C. Shi, J. Deng, C. Diao, M. Rosin, V. Shrivastava, Z. Batulan, J. Liu, E. R. O'Brien
This study compares the effects of HSP25 vaccination and estrogen therapy on atherogenesis in post-menopausal mice, finding that both reduce plaque but through different mechanisms involving PCSK9 and LDLR.
bioRxiv · Jun 4, 2020Pathology