C. Shi

Mechanical evolution of metastatic cancer cells in three-dimensional microenvironment

This study uses optical Brillouin microscopy to analyze mechanical features of cancer spheroids over time, showing improved classification accuracy using these features.

On the discovered Cancer Driving Nucleotides (CDNs)-Distributions across genes, cancer types and patients

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

Fes-deficient macrophages enhance CD8+ T cell priming and tumour control through increased proinflammatory cytokine production and localization

Nascent RNA kinetics with complex promoter architecture: Analytic results and parameter inference

This study introduces a stochastic model to analyze nascent RNA kinetics with complex promoters and develops a method to infer promoter memory from stationary RNA distributions, validated on synthetic and HIV-1 data.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

Long noncoding RNA Hottip maintained skeletal homeostasis via suppressing the enhancer of zeste homolog 2 (Ezh2)/histone methylation regulatory axis

This study identifies Hottip as a regulator of skeletal homeostasis by suppressing the Ezh2/histone methylation axis, affecting osteoblast and osteoclast differentiation.

The genetic evolution of acral melanoma

This study analyzes exome sequencing data from acral melanoma patients to identify distinct genetic evolution patterns compared to sun-exposed melanomas.

Deep learning classification of ex vivo human colon tissues using spectroscopic OCT

This study uses deep learning to classify ex vivo human colon tissues with spectroscopic OCT, achieving 88.9% accuracy in distinguishing tissue types.

CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota

This study shows ASB3 worsens inflammatory bowel disease by destabilizing TRAF6 and altering gut microbiota, suggesting ASB3 inhibition could be a therapeutic strategy.

Spatial and temporal distribution of ribosomes in single cells reveals aging differences between old and new daughters of Escherichia coli

The paper examines ribosome distribution in old and new daughters of E. coli, finding denser ribosomes in new daughters, suggesting a fundamental upstream process affecting ribosomal abundance during aging.

Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

Ferroptosis induced by phenolic compound-iron complex

This study shows phenolic compounds induce ferroptosis via iron complex formation, leading to cell death in bacteria and mammals, with potential therapeutic and biotechnological applications.

Activation of peroxisome proliferator-activated receptor-gamma prevents monocrotaline-induced pulmonary arterial hypertension by suppressing of nuclear factor-kappa B mediated autophagy

This study shows that activating PPAR-gamma reduces pulmonary arterial hypertension by inhibiting NF-kappa B-mediated autophagy in a rat model.

A versatile multimodal optical modality based on Brillouin light scattering and photoacoustic effect

This paper introduces a new multimodal optical imaging technique combining Brillouin and photoacoustic microscopy to measure mechanical, optical, and acoustical properties of biological samples with high resolution.

Development of Fully Human, Bispecific Antibodies that Effectively Block Omicron Variant Pseudovirus Infections

This study develops fully human bispecific antibodies that effectively block Omicron variant pseudovirus infections, showing improved neutralization compared to monoclonal antibodies.

Heterogeneity of Glycan Biomarker Clusters as an Indicator of Recurrence in Pancreatic Cancer

The paper examines glycan biomarker clusters in pancreatic cancer tumors to identify recurrence indicators using spatial analysis of immunofluorescence data.

Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

This paper introduces a vortex ultrasound technique for endovascular sonothrombolysis that significantly improves clot lysis rates in cerebral venous sinus thrombosis.

Vascular endothelial growth factor A contributes to the increasing of mammalian respiratory epithelial permeability induced by Pasteurella multocida infection

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

Global mosquito virome profiling and mosquito spatial diffusion pathways revealed by marker-viruses

The paper profiles global mosquito viromes across species, locations, and climates, identifies core-viruses, and links viral diversity to ecological factors and mosquito movement.

Digital Spatial Profiling of Intraductal Papillary Mucinous Neoplasms: Towards a Molecular Framework for Risk Stratification

The paper uses spatial RNA profiling to identify molecular markers and insights into malignant progression in intraductal papillary mucinous neoplasms (IPMN).

Tubule jamming in the developing mouse kidney creates cyclical mechanical stresses in nephron-forming niches

The paper investigates how crowding in developing mouse kidney tubules creates mechanical stresses in nephron-forming niches, revealing how spatial constraints influence branching and nephron formation.

Single-cell analysis of skeletal muscle macrophages reveals age- associated functional subpopulations

This study identifies age-associated functional subpopulations of skeletal muscle macrophages using single-cell transcriptomics in mice.

Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

Synergistic interaction of hyposalinity stress with Vibrio infection causes mass mortalities in oysters by inducing host microflora imbalance and immune dysregulation

This study shows hyposalinity stress and Vibrio infection synergistically cause oyster mortality by disrupting microbial balance and triggering immune dysregulation.

Dynamic surveillance of mosquitoes and their viromes in Wuhan during 2020.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.

Successional stages in infant gut microbiota maturation

The paper investigates infant gut microbiota maturation over the first year, identifying three conserved stages and associating disease and antibiotic use with stage regression.

Phosphorylation-dependent routing of RLP44 towards brassinosteroid or phytosulfokine signalling

This study shows that phosphorylation of RLP44's C-terminal tail directs its localization to either brassinosteroid or phytosulfokine signalling pathways.