In vitro teratogenicity testing using a 3D, embryo-like gastruloid system
V. Mantziou, P. Baillie-Benson, M. Jaklin, S. Kustermann, A. Martinez Arias, N. Moris
This study uses a 3D gastruloid model to assess teratogenicity of seven reference compounds in mouse and human systems, showing morphological and gene expression changes indicative of developmental defects.
bioRxiv · Mar 30, 2021Pharmacology & Toxicology