Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes
T. Bhardwaj, K. Gadhave, S. K. Kapuganti, P. Kumar, Z. F. Brotzakis, K. U. Saumya, N. Nayak, A. Kumar, N. Garg, M. Vendruscolo, R. Giri
This study investigates protein aggregation in SARS-CoV and SARS-CoV-2 proteomes, finding that several SARS-CoV-2 proteins form cytotoxic aggregates via a nucleation-dependent mechanism.
bioRxiv · May 29, 2021Biophysics