R. Giri

A truncation mutant of adenomatous polyposis coli (APC) impairs apical cell extrusion through elevated epithelial tissue tension

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

Curcumin Inhibits Zika Virus NS3 Helicase Activity

This study investigates curcumin's inhibitory effect on ZIKV NS3 helicase activity, finding it interacts with the enzyme and inhibits NTPase activity with an IC50 of 64.42 μM.

Met58 and di-acidic motif located at C-terminal region of SARS-CoV-2 ORF6 plays a crucial role in its structural conformations

The paper investigates the structural dynamics of the C-terminal region of SARS-CoV-2 ORF6, identifying key residues like Met58 and di-acidic motifs that influence its structural conformations and functional properties.

Discovery And Characterization of Small Molecule Inhibitors of Zika Virus Replication

This study identifies compound F1289-0194 as a potential inhibitor of Zika virus replication through molecular docking, dynamics simulations, and in vitro testing.

Investigating the folding dynamics of NS2B protein of Zika virus

This study investigates the folding dynamics of Zika virus NS2B protein, revealing conserved structural features and disordered-to-helix transitions under specific conditions.

Structural dynamics of Zika Virus NS1 via a reductionist approach reveal the disordered nature of its beta roll domain in isolation

This study uses molecular dynamics simulations and experimental validation to show that the ZIKV NS1 beta-roll domain is intrinsically disordered and the beta-ladder domain is highly flexible.

The aggregation potential of Zika virus proteome

This study identifies aggregation-prone regions in the Zika virus proteome using computational tools and experimental validation, showing several viral proteins can form amyloid-like fibrils.

Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal

The paper investigates the binding of the FDA-approved drug Mitoxantrone dihydrochloride to the C-terminal region of SARS-CoV-2 NSP1 and suggests potential therapeutic implications.

Investigating the conformational dynamics of Zika virus NS4B protein

This study investigates the conformational dynamics of Zika virus NS4B protein using molecular dynamics simulations and experiments, identifying the cytosolic region as intrinsically disordered and showing its dynamic behavior under different conditions.

Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91-112 & 231-290 regions

This paper investigates the conformational dynamics of SARS-CoV-2 NSP6 protein, focusing on regions 91-112 and 231-290 outside the membrane, using molecular dynamics simulations and reductionist approaches.

Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes

This study investigates protein aggregation in SARS-CoV and SARS-CoV-2 proteomes, finding that several SARS-CoV-2 proteins form cytotoxic aggregates via a nucleation-dependent mechanism.

P53 TAD2 Domain (38-61) Forms Amyloid-like Aggregates in Isolation

This study investigates the aggregation behavior of the P53 TAD2 domain (38-61) in isolation, showing it forms amyloid-like aggregates under acidic pH conditions.

Environmental Dependence of the Structure of the C-terminal Domain of the SARS-CoV-2 Envelope Protein

This paper investigates how environmental factors affect the conformation of the C-terminal domain of the SARS-CoV-2 envelope protein, showing it transitions between disordered, membrane-bound, and amyloid states.

Zika Virus Capsid Anchor Forms Cytotoxic Amyloid-like Fibrils

This study investigates the amyloid-forming propensity of the Zika virus Capsid-anchor (CA) peptide and shows it forms cytotoxic amyloid-like fibrils.

Conformational Dynamics of NSP11 Peptide of SARS-CoV-2 Under Membrane Mimetics and Different Solvent Conditions

This study investigates the conformational dynamics of SARS-CoV-2 nsp11 peptide under different membrane mimetics and solvent conditions, revealing its disordered nature and helical propensity in specific environments.

SARS-CoV-2 NSP1 C-terminal region (residues 130-180) is an intrinsically disordered region

This study investigates the conformational dynamics of SARS-CoV-2 NSP1 C-terminal region in isolation and under different solvent environments, finding it intrinsically disordered with conformational changes induced by SDS, TFE, and DOPC.

Secreted microbial metabolites modulate gut immunity and inflammatory tone

The paper identifies gut bacteria that suppress NF-κB activity and inflammatory responses, suggesting microbiome modulation as a potential therapeutic strategy for IBD.

Mechanistic insights into Zika virus NS3 helicase inhibition by Epigallocatechin-3-gallate

This study investigates how EGCG inhibits ZIKV NS3 helicase through molecular docking, simulation, and enzymatic assays, showing significant NTPase inhibition with an IC50 of 295.7 nM.