FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells
X. Wang, S. Geng, J. Meng, N. Kang, X. Liu, Y. Xu, H. Lv, Y. Xu, X. Xu, X. Song, B. Zhang, X. Wang, N. Nuerbulati, Z. Zhang, D. Zhai, , Y. Shi
This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.
bioRxiv · May 2, 2022 · PreprintImmunology