Author

N. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

A. Beilhack· 1 shared A. Dicker· 1 shared A. M. Giusti· 1 shared A. Seelig· 1 shared A.-K. Wolf· 1 shared D. Padula· 1 shared F. Herting· 1 shared F. Osl· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Beilhack

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2 papers

Recent·Most cited

ROCKETS - a novel one-for-all toolbox for light sheet microscopy in drug discovery

J. P. Mueller, M. Dobosz, N. O'Brien, A. M. Giusti, M. Lechmann, F. Osl, A.-K. Wolf, M. Sauer, F. Herting, P. Umana, T. Poeschinger, A. Beilhack

ROCKETS provides a standardized protocol for processing and imaging mouse tissues with LSFM, enabling comprehensive biodistribution analysis of immunotherapies.

Frontiers in Immunology · Feb 7, 2023Peer-reviewedPharmacology & Toxicology

Islet vascularization is regulated by primary endothelial cilia via VEGF-A dependent signaling

Y. Xiong, M. J. Scerbo, A. Seelig, F. Volta, N. O'Brien, A. Dicker, D. Padula, H. Lickert, J. M. Gerdes, P.-O. Berggren

This study shows that primary endothelial cilia regulate islet vascularization and vascular barrier function through VEGF-A/VEGFR2 signaling, with impaired vascularization observed in Bbs4-/- mice.

bioRxiv · Jun 13, 2019Physiology