Author

P.-O. Berggren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

A. Dicker· 2 shared Y. Xiong· 2 shared A. Seelig· 1 shared D. L. Silver· 1 shared D. Padula· 1 shared E. G. Y. Chew· 1 shared E. Ilegems· 1 shared F. T. Torta· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPhysiology

A. Dicker

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Author profile →

3 papers

Recent·Most cited

Diet-induced obesity results in endothelial cell desensitization to VEGF-A and permanent islet vascular dysfunction

Y. Xiong, A. Dicker, M. Visa, E. Ilegems, P.-O. Berggren

This study shows that diet-induced obesity causes permanent vascular dysfunction in pancreatic islets by desensitizing endothelial cells to VEGF-A, impairing glucose homeostasis.

bioRxiv · Nov 6, 2023 · PreprintPhysiology

Destabilization of β-cell FIT2 by saturated fatty acids contribute to ER stress and diabetes

X. Zheng, Q. W. C. Ho, M. Chua, O. Stelmashenko, S. Muralidharan, F. T. Torta, E. G. Y. Chew, M. M. Lian, J. N. Foo, M. R. Wenk, D. L. Silver, P.-O. Berggren, Y. Ali

This study shows that saturated fatty acids reduce β-cell lipid droplets by destabilizing FIT2, leading to ER stress and diabetes, while FIT2 overexpression protects against these effects.

bioRxiv · Feb 28, 2021 · PreprintBiochemistry

Islet vascularization is regulated by primary endothelial cilia via VEGF-A dependent signaling

Y. Xiong, M. J. Scerbo, A. Seelig, F. Volta, N. O'Brien, A. Dicker, D. Padula, H. Lickert, J. M. Gerdes, P.-O. Berggren

This study shows that primary endothelial cilia regulate islet vascularization and vascular barrier function through VEGF-A/VEGFR2 signaling, with impaired vascularization observed in Bbs4-/- mice.

bioRxiv · Jun 13, 2019Physiology