Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms
S. X. Van Ravenstein, K. P. Mehta, T. Kavlashvili, J. A. Byl, R. Zhao, N. Osheroff, D. Cortez, J. M. Dewar
This study shows etoposide and doxorubicin inhibit DNA replication through distinct mechanisms in Xenopus and human cells, despite shared Top2-dependent cytotoxicity.
bioRxiv · Oct 12, 2021Biochemistry