Author

J. M. Dewar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Xenopus· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

T. Kavlashvili· 3 shared B. F. Eichman· 1 shared B. H. Greer· 1 shared D. Cortez· 1 shared D. R. Heintzman· 1 shared J. A. Byl· 1 shared K. L. Rose· 1 shared K. P. Mehta· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

T. Kavlashvili

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Author profile →

3 papers

Recent·Most cited

RTEL1 and MCM10 overcome topological stress during vertebrate replication termination

L. V. Campos, B. H. Greer, D. R. Heintzman, T. Kavlashvili, W. H. McDonald, K. L. Rose, B. F. Eichman, J. M. Dewar

The paper identifies RTEL1 and MCM10 as proteins that help replication forks overcome topological stress during DNA synthesis termination in Xenopus egg extracts.

bioRxiv · Jan 27, 2022Biochemistry

Replication Fork Uncoupling Causes Nascent Strand Degradation and Fork Reversal

T. Kavlashvili, J. M. Dewar

This study shows that replication fork uncoupling leads to nascent strand degradation and fork reversal, with the helicase remaining bound during these processes.

bioRxiv · Oct 13, 2021Biochemistry

Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms

S. X. Van Ravenstein, K. P. Mehta, T. Kavlashvili, J. A. Byl, R. Zhao, N. Osheroff, D. Cortez, J. M. Dewar

This study shows etoposide and doxorubicin inhibit DNA replication through distinct mechanisms in Xenopus and human cells, despite shared Top2-dependent cytotoxicity.

bioRxiv · Oct 12, 2021Biochemistry