Author

N. R. Bennett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

D. Baker· 2 shared J. L. Watson· 2 shared P. J. Y. Leung· 2 shared S. Vazquez Torres· 2 shared A. H.-W. Yeh· 1 shared A. J. Borst· 1 shared A. N. Hoofnagle· 1 shared B. Huang· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioengineering

D. Baker

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Author profile →

2 papers

Recent·Most cited

Atomically accurate de novo design of antibodies with RFdiffusion

N. R. Bennett, J. L. Watson, R. J. Ragotte, A. J. Borst, D. L. See, C. Weidle, R. Biswas, Y. Yu, E. L. Shrock, R. Ault, P. J. Y. Leung, B. Huang, I. Goreshnik, J. Tam, K. D. Carr, , D. Baker

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

bioRxiv · Mar 14, 2024Bioengineering

De novo design of high-affinity protein binders to bioactive helical peptides

S. Vazquez Torres, P. J. Y. Leung, I. D. Lutz, P. Venkatesh, J. L. Watson, F. Hink, H.-H. Huynh, A. H.-W. Yeh, D. Juergens, N. R. Bennett, A. N. Hoofnagle, E. Huang, M. J. MacCoss, M. Exposit, G. R. Lee, , D. Baker

This paper designs high-affinity protein binders for bioactive helical peptides using deep learning and generative models, achieving picomolar affinity without experimental optimization.

bioRxiv · Dec 10, 2022 · PreprintBioengineering