Author

R. J. Ragotte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Bioengineering· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:deep learning· 3 Research Focus:protein design· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:protein structure· 2 Assay:proteomics· 2

Frequent Co-Authors

B. I. M. Wicky· 3 shared D. Baker· 3 shared S. J. Draper· 3 shared A. Courbet· 2 shared A. Kang· 2 shared A. M. Lias· 2 shared B. G. Williams· 2 shared D. Pulido· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

B. I. M. Wicky

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Author profile →

6 papers

Recent·Most cited

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

B. G. Williams, L. D. W. King, D. Pulido, D. Quinker, A. M. Lias, S. E. Silk, R. J. Ragotte, H. Davies, J. R. Barrett, K. McHugh, C. A. Rigby, D. G. W. Alanine, L. Barfod, M. W. Shea, L. A. Cowley, , S. J. Draper

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

Nature Communications · Jun 7, 2024Peer-reviewedImmunology

Atomically accurate de novo design of antibodies with RFdiffusion

N. R. Bennett, J. L. Watson, R. J. Ragotte, A. J. Borst, D. L. See, C. Weidle, R. Biswas, Y. Yu, E. L. Shrock, R. Ault, P. J. Y. Leung, B. Huang, I. Goreshnik, J. Tam, K. D. Carr, , D. Baker

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

bioRxiv · Mar 14, 2024Bioengineering

The Dual Action of Human Antibodies Specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites

G. E. Weiss, R. J. Ragotte, D. Quinkert, A. M. Lias, M. G. Dans, C. Boulet, B. G. Williams, B. S. Crabb, S. J. Draper, P. R. Gilson

This paper shows that antibodies against PfRH5 and PfCyRPA block parasite invasion and inactivate extracellular merozoites by triggering a developmental pathway normally seen after invasion.

bioRxiv · Feb 7, 2023 · PreprintMicrobiology

Hallucinating protein assemblies

B. I. M. Wicky, L. F. Milles, A. Courbet, R. J. Ragotte, J. Dauparas, E. Kinfu, S. Tipps, R. D. Kibler, M. Baek, F. DiMaio, X. Li, L. Carter, A. Kang, H. Nguyen, A. K. Bera, D. Baker

Deep network-based protein design generates symmetric homo-oligomers with high structural accuracy, demonstrating the potential for creating novel nanomachines and biomaterials.

Science · Oct 7, 2022Peer-reviewedBiophysics

Robust deep learning based protein sequence design using ProteinMPNN

J. Dauparas, I. Anishchenko, N. Bennett, H. Bai, R. J. Ragotte, L. F. Milles, B. I. M. Wicky, A. Courbet, R. J. de Haas, N. Bethel, P. J. Y. Leung, T. F. Huddy, S. Pellock, D. Tischer, F. Chan, , D. Baker

A deep learning method for protein sequence design shows high performance in both simulations and experiments, applicable to various design challenges.

bioRxiv · Jun 3, 2022Biophysics

Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein

R. J. Ragotte, D. Pulido, F. R. Donnellan, G. Gorini, H. Davies, J. Brun, L. D. King, K. Skinner, S. J. Draper

This study shows that SARS-CoV-2 spike glycoprotein does not directly interact with human basigin (CD147), challenging its role as a co-receptor for viral entry.

bioRxiv · Feb 22, 2021Biochemistry