Low-dose IFN-γ induces tumor cell stemness in tumor microenvironment of non-small cell lung cancer
Y. Zhang, M. Song, Y. Ping, K. Zhang, L. Yang, F. Li, S. Cheng, D. Yue, N. R. Maimela, J. Qu, S. Liu, T. Sun, Z. Li, J. Xia, B. Zhang, L. Wang
This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.
bioRxiv · Jan 11, 2019Cancer Biology