M. Song

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

Molecular basis for the interactions of eIF2β with eIF5, eIF2B, and 5MP1 and their regulation by CK2

This study investigates the molecular interactions of eIF2β with eIF5, eIF2B, and 5MP1 using crystallography and NMR, revealing binding sites and regulatory roles of CK2 phosphorylation.

Dynamic Mode Decomposition for Transient Cavitation Bubbles Imaging in Pulsed High Intensity Focused Ultrasound Therapy

This paper enhances Bubble Doppler imaging for transient cavitation bubbles using dynamic mode decomposition, showing improved performance over traditional filters in both simulated and ex vivo settings.

TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids

This study shows that OSCA/TMEM63 proteins, like TMEM16s, can permeate ions and phospholipids, highlighting conserved functional potential across the TCS superfamily.

Synaptic plasticity via receptor tyrosine kinase / G protein-coupled receptor crosstalk

The paper identifies a novel form of hippocampal synaptic plasticity mediated by TrkB and mGluR5 crosstalk in response to BDNF.

Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

Mature microRNA-binding protein QKI promotes microRNA-mediated gene silencing

The paper identifies QKI as a novel microRNA-binding protein that enhances AGO2/let-7b-mediated gene silencing and suppresses tumor growth.

Functional traits trade-offs define plant population stability worldwide

The paper examines global plant population stability by linking trait trade-offs to inter-annual variability in species abundance across multiple ecosystems.

Drastic differential CRISPR-Cas9 induced mutagenesis influenced by DNA methylation and chromatin features

This study shows that chromatin features and DNA methylation significantly affect CRISPR-Cas9 mutagenesis efficiency and mutation profiles in Arabidopsis thaliana.

Limited consequences for loss of RNA-directed DNA methylation in Setaria viridis domains rearranged methyltransferase (DRM) mutants

This study examines the effects of losing RNA-directed DNA methylation in Setaria viridis by analyzing methylation patterns and gene expression in drm1ab mutants, finding limited morphological and transcriptional consequences.

THEMIS is a priming substrate of non-receptor tyrosine phosphatase PTPN6/SHP1 and plays dual roles during T cell development

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

The genomic context for aflatoxin B1-degrading Pseudomonas strains

The paper sequences and annotates three Pseudomonas strains, finding that AFB1-degrading strains have more genes related to xenobiotic metabolism and oxidoreductase activity.

Therapeutic efficacy of CT-P59 against P.1 variant of SARS-CoV-2

This study evaluates CT-P59's efficacy against the P.1 SARS-CoV-2 variant through in vitro and in vivo tests, showing reduced in vitro neutralization but therapeutic benefit in mice.

Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents

The paper validates in vitro human lung tissue models for studying SARS-CoV-2 and influenza virus infections and antiviral treatments.

RHAMMB-mediated bifunctional nanotherapy targeting Bcl-xL and mitochondria for pancreatic neuroendocrine tumor treatment

This paper develops a RHAMMB-targeting nanoparticle delivering siBcl-xL and KLA peptide to treat PNETs, showing synergistic tumor reduction in mice.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

Interactive Web-based Annotation of Plant MicroRNAs with iwa-miRNA

The paper introduces iwa-miRNA, a web-based tool for interactive annotation of plant miRNAs using sRNA-Seq data and manual curation.

Soluble Spike DNA vaccine provides long-term protective immunity against SAR-CoV-2 in mice and nonhuman primates

This study develops a DNA vaccine against SARS-CoV-2, GX-19, showing protective immunity in mice and nonhuman primates with durable antibody and T cell responses.

Molecular mechanism of SARS-Cov-2 components caused ARDS in murine model

This study develops a non-infectious murine model to study SARS-CoV-2-induced ARDS and CSS, and identifies potential therapeutic agents that alleviate inflammatory symptoms.

Global variability of the human IgG glycome

The paper analyzes global variability in IgG glycosylation across populations, finding that country of residence and socioeconomic development strongly influence glycan features and monogalactosylation levels.

Low-dose IFN-γ induces tumor cell stemness in tumor microenvironment of non-small cell lung cancer

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.