Dwarf open reading frame (DWORF) peptide is a direct activator of the sarcoplasmic reticulum calcium pump SERCA.
M. E. Fisher, E. Bovo, E. E. Cho, M. P. Pribadi, M. P. Dalton, M. J. Lemieux, N. Rathod, R. Aquayo-Ortiz, L. M. Espinoza-Fonseca, S. L. Robia, A. V. Zima, H. S. Young
This paper identifies DWORF as a direct activator of SERCA, increasing its turnover rate and calcium reuptake, contrasting with the inhibitory effect of phospholamban.
bioRxiv · Oct 1, 2020Biophysics