H. S. Young

SARS-CoV-2 Mpro protease variants of concern display altered viral and host target processing but retain potency towards antivirals

The paper examines how SARS-CoV-2 Mpro variants affect viral and host protein processing but maintain antiviral potency.

N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 Mpro

This study characterizes the reversible inhibition of SARS-CoV-2 and SARS-CoV Mpro by GC376, showing nanomolar Ki values and domain swapping in the drug-bound structures.

Dwarf open reading frame (DWORF) peptide is a direct activator of the sarcoplasmic reticulum calcium pump SERCA.

This paper identifies DWORF as a direct activator of SERCA, increasing its turnover rate and calcium reuptake, contrasting with the inhibitory effect of phospholamban.

Insights into the catalytic properties of the mitochondrial rhomboid protease PARL

This study investigates the catalytic properties of the mitochondrial rhomboid protease PARL using in vitro assays, revealing substrate preferences and activity enhancements under specific conditions.

Sarcolambans are phospholamban- and sarcolipin-like regulators of the sarcoplasmic reticulum calcium pump SERCA

The paper investigates sarcolamban peptides from invertebrates to determine their regulatory effects on SERCA1a, finding they act as super-inhibitors with phospholamban-like or sarcolipin-like characteristics.

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

This paper shows that feline coronavirus drugs inhibit SARS-CoV-2 main protease and block virus replication in cell culture with low toxicity.

Protein Docking and Steered Molecular Dynamics Reveal Alternative Regulatory Sites on the SERCA Calcium Transporter

This study uses SMD and docking to test if PLB interacts with alternative sites on SERCA beyond the canonical site, finding that the canonical site is preferred but alternative sites are favorable under certain conditions.

Interaction of a sarcolipin pentamer and monomer with the sarcoplasmic reticulum calcium pump, SERCA

This paper characterizes the interaction between sarcolipin (SLN) pentamer and monomer with SERCA, revealing structural and functional insights into SLN's regulation of calcium transport and thermogenesis.

Interleukin-36 promotes systemic Type-I IFN responses in severe psoriasis.

The paper identifies an IL-36/TLR-9/Type-I IFN axis that drives systemic inflammation in psoriasis, offering a potential therapeutic target.

The phospholamban pentamer interacts with the sarcoplasmic reticulum calcium pump SERCA.

This paper shows that phospholamban pentamer interacts with SERCA in both crystal forms, playing structural and functional roles in its regulation.