Inhibitory and Stimulatory Micropeptides Preferentially Bind to Different Conformations of the Cardiac Calcium Pump
S. R. Cleary, X. Fang, E. E. Cho, M. P. Pribadi, J. Seflova, J. R. Beach, P. Kekenes-Huskey, S. L. Robia
The paper shows that inhibitory and stimulatory micropeptides bind to different conformations of the cardiac calcium pump SERCA, with their binding preference depending on intracellular Ca2+ levels.
bioRxiv · Jun 15, 2021Biophysics