Alpha-synuclein pre-formed fibrils injected into prefrontal cortex primarily spread to cortical and subcortical structures and lead to isolated behavioral symptoms
M. A. Weber, G. Kerr, R. Thangavel, M. M. Conlon, H. A. Abdelmotilib, O. Halhouli, Q. Zhang, J. C. Geerling, N. S. Narayanan, G. M. Aldridge
This study injects alpha-synuclein pre-formed fibrils into the prefrontal cortex of mice, showing spread to cortical and subcortical regions and mild behavioral changes.
bioRxiv · Jan 31, 2023Animal Behavior & Cognition