Extracellular Matrix Stiffness Alters TRPV4 Regulation in Chondrocytes
N. S. Trompeter, C. J. Farino, M. Griffin, R. Skinner, O. A. Banda, J. P. Gleghorn, J. H. Slater, R. L. Duncan
This study shows that softer cartilage substrates reduce TRPV4-mediated calcium influx and increase chondrocyte apoptosis, which can be mitigated by TRPV4 agonism.
bioRxiv · Sep 14, 2021 · PreprintCell Biology