Insulin-like Growth Factor-1 Regulates the Mechanosensitivity of Chondrocytes by Modulating TRPV4
N. S. Trompeter, J. D. Gardinier, V. M. DeBarros, M. Boggs, V. Gangadharan, W. J. Cain, L. Hurd, R. L. Duncan
This study shows IGF-1 modulates TRPV4 channel activity in chondrocytes by increasing cell stiffness, reducing hypotonic-induced calcium flux and ATP release.
bioRxiv · Mar 10, 2020Cell Biology