A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration
M. Tautou, S. Eddarkaoui, F. Descamps, P.-E. Larchanche, M. Dumoulin, C. Lamarre, D. Blum, L. Buee, P. Melnyk, N. Sergeant
The paper identifies two β-secretase modulators, MAGS02-14 and PEL24-199, and shows that PEL24-199 reduces Tau pathology and improves short-term memory in a mouse model of neurofibrillary degeneration.
bioRxiv · Apr 2, 2021Pharmacology & Toxicology