Author

D. Blum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Organism:yeast· 1

Frequent Co-Authors

C. Gatsogiannis· 2 shared M. Chen· 2 shared R. Wagner· 2 shared A. Harris· 1 shared C. Gertzen· 1 shared C. Lamarre· 1 shared F. Descamps· 1 shared L. Buee· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

C. Gatsogiannis

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A new twist in ABC transporter mediated multidrug resistance - Pdr5 is a drug/proton co-transporter

M. Wagner, D. Blum, S. Raschka, L.-M. Nentwig, C. Gertzen, M. Chen, C. Gatsogiannis, A. Harris, S. Smits, R. Wagner, L. Schmitt

This study shows Pdr5, an ABC transporter, functions as a proton/drug co-transporter, generating a proton motive force during drug efflux, suggesting a more complex mechanism of multidrug resistance.

bioRxiv · May 26, 2021Biochemistry

Molecular architecture of black widow spider neurotoxins

M. Chen, D. Blum, L. Engelhard, S. Raunser, R. Wagner, C. Gatsogiannis

This study reports cryoEM structures of two Latrotoxins (LaTXs) and proposes a cyclic oligomerization mechanism, revealing structural insights into their molecular action.

bioRxiv · Apr 19, 2021Biophysics

A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration

M. Tautou, S. Eddarkaoui, F. Descamps, P.-E. Larchanche, M. Dumoulin, C. Lamarre, D. Blum, L. Buee, P. Melnyk, N. Sergeant

The paper identifies two β-secretase modulators, MAGS02-14 and PEL24-199, and shows that PEL24-199 reduces Tau pathology and improves short-term memory in a mouse model of neurofibrillary degeneration.

bioRxiv · Apr 2, 2021Pharmacology & Toxicology