L. Buee

Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein

The paper optimizes VHH antibodies targeting Tau's PHF6 peptide through mutagenesis and screening, showing improved binding and aggregation inhibition, but also highlighting the importance of stability beyond affinity.

A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration

The paper identifies two β-secretase modulators, MAGS02-14 and PEL24-199, and shows that PEL24-199 reduces Tau pathology and improves short-term memory in a mouse model of neurofibrillary degeneration.

Role of TNF-α among inflammatory molecules secreted by injured astrocytes in the modulation of in vitro neuronal networks

This study investigates how TNF-α secreted by injured astrocytes affects neuronal network growth and synaptic connections in vitro.