Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
M. D. Larsen, M. Lopez-Perez, E. K. Dickson, P. Ampomah, N. T. Ndam, J. Nouta, C. A. M. Koeleman, A. L. H. Ederveen, B. Mordmüller, A. Salanti, M. A. Nielsen, A. Massougbodji, C. E. van der Schoot, M. F. Ofori, M. Wuhrer, , G. Vidarsson
The paper shows that natural infection with Plasmodium falciparum induces afucosylated PfEMP1-specific IgG, while subunit vaccination produces fully fucosylated IgG.
bioRxiv · Apr 23, 2021Immunology