G. Vidarsson

IgG hexamers initiate acute lung injury

This study shows that IgG hexamerization is critical for triggering acute lung injury and suggests therapeutic strategies targeting hexamer formation.

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

The paper identifies SYK and PI3K inhibitors, particularly entospletinib, as effective in counteracting anti-spike IgG-induced hyperinflammation in severe COVID-19.

Humans have distinct repertoires of IgA1

This study identifies two distinct structural populations of IgA1 in human serum and milk, with different clonal repertoires and origins.

The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylatedIgG1 in naive but not antigen-experienced vaccinees

The paper examines afucosylated IgG1 responses after BNT162b2 vaccination, finding transient responses in naive individuals that correlate with second-dose antibody levels.

Staphylococcal protein A inhibits IgG-mediated phagocytosis by blocking the interaction of IgGs with FcγRs and FcRn

Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

The paper shows that natural infection with Plasmodium falciparum induces afucosylated PfEMP1-specific IgG, while subunit vaccination produces fully fucosylated IgG.

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases

This study shows that C1r2s2 proteases stabilize C1q binding to surface-bound IgG, with subclass-specific effects and improved phagocytosis with hexamer-enhanced IgGs.

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients induces hyper-inflammatory responses in macrophages, leading to endothelial barrier breakdown and microvascular thrombosis.

Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19

The paper shows that afucosylated IgG responses are common in enveloped virus infections and are more severe in COVID-19, with implications for immune response and pathology.

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

This study isolates potent neutralizing antibodies from COVID-19 patients that target multiple sites on the SARS-CoV-2 spike protein, offering insights for vaccine design and therapeutic development.

Site-specific glycosylation mapping of Fc gamma receptor IIIb from neutrophils of health donors

This study maps glycosylation sites of Fc gamma receptor IIIb from neutrophils using LC-MS/MS and identifies donor allotype differences.

Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation

The paper examines how RSV-specific antibodies from infants with severe respiratory infections activate NK cells and links this to Fc-glycosylation, finding reduced activation in infected infants.

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering

This study presents a CRISPR/HDR platform to engineer hybridoma antibodies for diverse isotypes, formats, and species, enabling functional antibody diversification.