High-throughput binding affinity measurements for mutations spanning a transcription factor-DNA interface reveal affinity and specificity determinants
A. K. Aditham, C. J. Markin, D. A. Mokhtari, N. V. DelRosso, P. M. Fordyce
The paper measures binding affinities of TF mutants and DNA variants to identify affinity and specificity determinants in the TF-DNA interface.
bioRxiv · Jun 22, 2020Biophysics