Author

D. A. Mokhtari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

P. M. Fordyce· 4 shared C. J. Markin· 3 shared D. Herschlag· 3 shared F. Sunden· 2 shared S. Du· 2 shared S. Longwell· 2 shared T. Doukov· 2 shared A. K. Aditham· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersBiochemistry

P. M. Fordyce

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Author profile →

5 papers

Recent·Most cited

High-throughput enzymology reveals mutations throughout a phosphatase that decouple catalysis and transition state analog affinity

C. J. Markin, D. A. Mokhtari, S. Du, T. Doukov, F. Sunden, P. M. Fordyce, D. Herschlag

This study uses HT-MEK to analyze 1,004 PafA mutants, showing that distal mutations affect catalysis more than TSA binding, suggesting conformational changes influence enzyme function.

bioRxiv · Nov 7, 2022 · PreprintBiochemistry

A microwell platform for high-throughput longitudinal phenotyping and selective retrieval of organoids

A. Sockell, W. Wong, S. Longwell, T. Vu, K. Karlsson, D. A. Mokhtari, J. Schaepe, Y.-H. Lo, V. Cornelius, C. Kuo, D. A. Van Valen, C. Curtis, P. M. Fordyce

This paper introduces a microwell platform for high-throughput longitudinal phenotyping of organoids and their selective retrieval for molecular profiling, identifying genomic and expression changes linked to growth and polarity.

bioRxiv · Nov 1, 2022Bioengineering

Damaged goods? Evaluating the impact of X-ray damage on conformational heterogeneity in room temperature and cryo-cooled protein crystals

F. Yabukarski, T. Doukov, D. A. Mokhtari, S. Du, D. Herschlag

This study evaluates how X-ray damage affects conformational heterogeneity in protein crystals at room temperature and cryo-cooled conditions, finding that damage effects can be minimized or eliminated.

bioRxiv · Jun 27, 2021 · PreprintBiophysics

Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics

C. J. Markin, D. A. Mokhtari, F. Sunden, M. J. Appel, E. Akiva, S. Longwell, C. Sabatti, D. Herschlag, P. M. Fordyce

HT-MEK, a microfluidic platform, reveals enzyme architectures shaping function through high-throughput kinetic analysis of enzyme variants.

bioRxiv · Nov 24, 2020Biochemistry

High-throughput binding affinity measurements for mutations spanning a transcription factor-DNA interface reveal affinity and specificity determinants

A. K. Aditham, C. J. Markin, D. A. Mokhtari, N. V. DelRosso, P. M. Fordyce

The paper measures binding affinities of TF mutants and DNA variants to identify affinity and specificity determinants in the TF-DNA interface.

bioRxiv · Jun 22, 2020Biophysics