Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context
S. Bali, R. Singh, P. M. Wydorski, N. van Nuland, A. Wosztyl, V. A. Perez, d. chen, J. Chen, J. Rizo, L. A. Joachimiak
This study shows that tau aggregation can be reduced by modifying sequences near the PGGG β-turn motif, while maintaining microtubule binding, offering therapeutic insights for neurodegenerative diseases.
bioRxiv · Dec 13, 2023Biophysics