V. A. Perez

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context

This study shows that tau aggregation can be reduced by modifying sequences near the PGGG β-turn motif, while maintaining microtubule binding, offering therapeutic insights for neurodegenerative diseases.

Dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification

This study investigates how exogenous tau seeds are cleared or amplified within cells, finding they are mostly lysosomally degraded but a small fraction enters the cytosol to replicate and is cleared by the proteasome.

DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation

This study identifies DnaJC7's interaction with tau's beta-turn element to inhibit amyloid formation, suggesting a mechanism for tau aggregation regulation.

Tau local structure shields amyloid motif and controls aggregation propensity

The paper investigates how local structure in tau protein modulates aggregation propensity and how mutations disrupt this structure to trigger amyloid formation.