J. Rizo

A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release

This paper proposes a lever hypothesis for Synaptotagmin-1 action in neurotransmitter release, suggesting it pulls SNARE complexes to facilitate membrane fusion.

Control of Munc13-1 Activity by Autoinhibitory Interactions Involving the Variable N-terminal Region

This study investigates how the N-terminal region of Munc13-1 inhibits its activity and how this inhibition is relieved by RIMs and calmodulin.

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context

This study shows that tau aggregation can be reduced by modifying sequences near the PGGG β-turn motif, while maintaining microtubule binding, offering therapeutic insights for neurodegenerative diseases.

Molecular mechanism underlying SNARE-mediated membrane fusion enlightened by all-atom molecular dynamics simulations

This study uses molecular dynamics simulations to propose a mechanism for SNARE-mediated membrane fusion, emphasizing local molecular events over general membrane properties.

Oxidative regulation of TDP-43 self-association by a beta-to-alpha conformational switch

This paper shows that oxidative modification of TDP-43's low complexity domain induces a beta-to-alpha conformational switch, disrupting self-association and phase separation.

SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex

The paper reports cryo-EM structures of a Munc18-1-syntaxin-1-synaptobrevin complex, revealing how Munc18-1 facilitates SNARE complex assembly by mediating interactions between syntaxin-1 and synaptobrevin.

All-atom molecular dynamics simulations of synaptic vesicle fusion I: a glimpse at the primed state

The paper uses molecular dynamics simulations to study the primed state of synaptic vesicles, revealing a spring-loaded configuration of trans-SNARE complexes bound to synaptotagmin-1 and complexin-1.

Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity

This study investigates how poly-glutamine sequences in the androgen receptor (AR) N-terminal domain influence its activity and interactions with KDM4A, suggesting a role for phase separation in regulating AR function in prostate cancer.

Synaptotagmin-1 and Doc2b exhibit distinct membrane remodeling mechanisms

This study compares how Synaptotagmin-1 and Doc2b remodel membranes through different mechanisms, revealing distinct roles in Ca2+-triggered secretion.