N. Zangger

Locally confined IFNγ production by CD4+ T cells provides niches for murine cytomegalovirus replication in the salivary gland

This study shows that CD4+ T cells produce IFNγ locally in clusters near MCMV infection foci in salivary glands, enabling regional protection while allowing continued viral replication.

Low STING expression in a transplantable KrasG12D/P53ko lung cancer model contributes to SiglecF+ neutrophil and CD103+Treg accumulation in tumors

The paper investigates the role of STING expression in lung cancer models, finding that low STING expression promotes an immunosuppressive tumor microenvironment with increased neutrophils and Tregs.

RANKL Signaling Sustains Primary Tumor Growth In Genetically Engineered Mouse Models Of Lung Adenocarcinoma

This study shows that blocking RANKL signaling reduces primary tumor growth in lung adenocarcinoma mouse models and suggests potential benefits for KRAS mutant lung cancer patients.