An ITK - SLP-76 Y173 Axis Regulates TCR Signal Persistence and Thymic Development
Manal Marzouk, J Perry, Enas Hallumi, Hirofumi Shibata, Zenia Kaul, Naama Klopstock, Dominic P. Golec, Leslie J. Berg, Pamela L. Schwartzberg, Deborah Yablonski
This study shows that the ITK-SLP-76 Y173 axis is essential for TCR signal persistence and thymic development, as its disruption reduces thymocyte cellularity and alters CD4/CD8 ratios.
bioRxiv · Oct 27, 2026 · PreprintImmunology