Dominic P. Golec

An ITK - SLP-76 Y173 Axis Regulates TCR Signal Persistence and Thymic Development

This study shows that the ITK-SLP-76 Y173 axis is essential for TCR signal persistence and thymic development, as its disruption reduces thymocyte cellularity and alters CD4/CD8 ratios.

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

PI3Kdelta promotes T cell effector differentiation and plasticity during chronic infection

This study shows that activated PI3Kdelta reduces TCF-1+ stem-like CD8+ T cells but promotes effector differentiation and viral control during chronic infection.

Optimal CXCR5 Expression during Tfh Maturation Involves the Bhlhe40-Pou2af1 Axis

This study identifies the Bhlhe40-Pou2af1 axis as a transcriptional regulator of CXCR5 expression in Tfh cells, independent of the Bcl6-Blimp1 pathway.

RasGRP1 Signalling Programs Developing γδ-Thymocytes towards the γδT17 Lineage Through Control of c-Maf Expression

This study shows RasGRP1 is essential for generating CD73+ γδ T cells and regulating c-Maf expression to drive γδT17 lineage commitment.

Spatial organization of pulmonary type 2 inflammation by a macrophage-derived cholesterol metabolite

The paper identifies a cholesterol metabolite that spatially organizes TH2 cells during fungal-induced pulmonary inflammation, promoting fungal persistence and suppressing interferon-gamma responses.

Sulfide is a keystone metabolite for gut homeostasis and immunity

This study shows that sulfide is essential for gut microbial and immune homeostasis, with its depletion causing immune dysfunction and impaired vaccine response.