Safe delivery of AAV vectors to the liver of small weaned pigs by ultrasound guided percutaneous transhepatic portal vein injection
Tanja Rothgangl, Martina Hruzova, Ralph Gnannt, Nadja Aeberhard, Lucas Kissling, Hiu Man Grisch‐Chan, Sven Klassa, Nicole Rimann, Kim Fabiano Marquart, Eleonora I. Ioannidi, Anja A. Wolf, Christian Kupatt, Xaver Sidler, Johannes Häberle, Gerald Schwank, Beat Thöny
The paper describes a minimally invasive method for delivering AAV vectors to pig livers but finds low vector retention and no detectable editing in vivo.
bioRxiv · Apr 5, 2023 · PreprintMolecular Biology