BindCraft: one-shot design of functional protein binders
Martin Pačesa, Lennart Nickel, Christian Schellhaas, Joseph H. Schmidt, Ekaterina Pyatova, Lucas Kissling, Patrick Barendse, Jagrity Choudhury, Srajan Kapoor, Ana Alcaraz‐Serna, Yehlin Cho, Kourosh H. Ghamary, Laura Vinué, Brahm J. Yachnin, Andrew M. Wollacott, , Bruno E. Correia
Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.
bioRxiv · Sep 30, 2024 · PreprintBioinformatics✦ In-depth digest