Lysophosphatidic acid receptor 1 influences disease severity in a mouse model of multiple sclerosis
Nagi Uemura, Nagisa Matsuo, Kazunao Taniyama, Hiroki Nakajima, Kazuki Nagayasu, Shuji Kaneko, Jerold J. M. Chun, Hiroshi Ueda, Hisashi Shirakawa
This study shows that LPA1 receptor activation worsens multiple sclerosis in mice by promoting microglial activation and immune cell infiltration, and that blocking LPA1 improves disease outcomes.
bioRxiv · May 28, 2024 · PreprintNeuroscience