Hisashi Shirakawa

This study shows TRPV4 activation increases IL10 production in microglia, reducing inflammation by suppressing pro-inflammatory cytokines.

This study shows that LPA1 receptor activation worsens multiple sclerosis in mice by promoting microglial activation and immune cell infiltration, and that blocking LPA1 improves disease outcomes.

This study shows that OPC depletion in the acute phase of EAE reduces neuroinflammation and demyelination by suppressing macrophage and T cell activation.

This study identifies gene expression changes in DRN serotonin neurons under antidepressant treatment and depression models, revealing S100a10 as a prodepressive gene and its regulatory pathway.