Shuji Kaneko

TRPV4 activation enhances LPS-induced IL10 production to suppress excessive microglial activation

This study shows TRPV4 activation increases IL10 production in microglia, reducing inflammation by suppressing pro-inflammatory cytokines.

Lysophosphatidic acid receptor 1 influences disease severity in a mouse model of multiple sclerosis

This study shows that LPA1 receptor activation worsens multiple sclerosis in mice by promoting microglial activation and immune cell infiltration, and that blocking LPA1 improves disease outcomes.

Oligodendrocyte precursor cells exacerbate acute CNS inflammation via macrophage and T cell activation in a mouse model of multiple sclerosis

This study shows that OPC depletion in the acute phase of EAE reduces neuroinflammation and demyelination by suppressing macrophage and T cell activation.

Transcriptional landscape of the dorsal raphe serotonin neurons rendering stress resiliency

This study identifies gene expression changes in DRN serotonin neurons under antidepressant treatment and depression models, revealing S100a10 as a prodepressive gene and its regulatory pathway.

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.