Jerold J. M. Chun

The paper shows that phosphorylation of anandamide by DGKQ converts it into AEAp, which acts as a ligand for LPARs and MRGPRX4, linking eCB metabolism to Cannabis pharmacology.

This study identifies PLA2G12A's role in Th17 differentiation through lysophospholipid signaling via extracellular vesicles, showing therapeutic potential for Th17-related diseases.

This study shows that ILC2s use different S1P receptors at distinct stages to migrate during infection, highlighting a shared vascular network for lymphocyte movement.

The paper uses multiomic single-cell and spatial data to identify gene regulatory networks and transcription factors driving cortical regionality in the human brain.

This paper develops a human lung organoid model to study senescence, showing increased β-gal activity, SASP cytokines, and fibrosis-like features.

This study shows that LPA1 receptor activation worsens multiple sclerosis in mice by promoting microglial activation and immune cell infiltration, and that blocking LPA1 improves disease outcomes.

The paper introduces DART-FISH, a multiplexed RNA in situ hybridization technique for high-resolution profiling of human tissues, demonstrating its application on brain and kidney samples.

The paper identifies a mechanism by which FTY720 reduces MS-like disease in an animal model through B12-TCN2-CD320 signaling in astrocytes.

The paper uses snRNA-seq to compare cell type-specific transcriptomic changes between RRMS and SPMS in non-lesioned brain regions, identifying downregulation of astrocytic sphingosine kinases in SPMS.

The paper compares cellular diversity in the primary motor cortex across human, marmoset, and mouse using single-nucleus transcriptomics and epigenomics, finding conserved cell types and species-specific adaptations.

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

This study validates an anti-LPA antibody (504B3) and finds it binds non-LPA lipids, suggesting potential off-target effects.

The paper uses single-cell multi-omics to analyze HARs and HGEs in fetal human brain development, identifying regulatory networks and key transcription factors involved in human-specific neurodevelopment.

This study shows that LPA1 receptor dysregulation in macrophages contributes to MS pathogenesis by promoting inflammation, with implications for therapeutic targeting.

The paper challenges claims of contamination by providing evidence of APP gencDNA insertion breakpoints in Alzheimer's disease samples and supporting the existence of somatic gene recombination.

This study identifies S1P as a key activator of the MAP3K1-JNK pathway, which drives epithelial cell movement and eyelid morphogenesis in mice.

The paper develops two single-cell methods to analyze human brain cells, identifies neuronal subtypes and non-neuronal cell types, and links genetic risk factors to specific cell types.