Microbiota-derived indole metabolites inhibit rotavirus infection in vitro and in vivo and in human infants
Nurul I. Wirusanti, Yannick van Schajik, Jongchan Kim, Josephine F. Frempong, Nagina Simkhada, Sydney Fisher, Nicholas Pucci, Gonçalo J. Piedade, Charlie Chaluma Luchen, Mwelwa Chibuye, Michelo Simuyandi, Caroline Cleopatra Chisenga, Suwilanji Silwamba, Kennedy Chibesa, Bertha T. Nzangwa, , Vanessa Harris
This study shows microbiota-derived indole metabolites inhibit rotavirus infection in human infants and animal models through the AhR pathway.
bioRxiv · Oct 29, 2025 · PreprintMicrobiology