A cell-free assay for rapid screening of inhibitors of hACE2-receptor - SARS-CoV-2-Spike binding
Nanami Kikuchi, Or Willinger, Naor Granik, Reut Gal, Noa Navon, Shanny Ackerman, Ella Samuel, Tomer Antman, Noa Katz, Sarah Goldberg, Roee Amit
The paper describes a cell-free assay using fluorescent particles and labeled hACE2 to screen inhibitors of SARS-CoV-2 Spike-hACE2 binding, demonstrating its effectiveness with known inhibitors and RNA-based trapping.
ACS Synthetic Biology · Apr 4, 2022Peer-reviewedSynthetic Biology