Naor Granik

Synthetic RNA-protein decoy granules to prevent SARS-CoV-2 infection

This paper introduces AntiCoV decoy particles, synthetic RNA-protein nanoparticles that inhibit SARS-CoV-2 infection by acting as stable decoy receptors, outperforming soluble ACE2 in neutralization.

High avidity phase-separated RNA-protein sialogranules sense lectins and inhibit influenza infection

The paper develops sialogranules that sense lectins and inhibit influenza infection by using sialylated RNA-protein nanoparticles.

Formation of polyphasic RNP granules by intrinsically disordered Qβ coat proteins and hairpin-containing RNA

The paper shows that synthetic RNA with hairpin binding sites and disordered coat proteins form programmable polyphasic RNP granules with tunable phase behavior.

Phase Separation-based Antiviral Decoy Particles as Basis for Programmable Broad-spectrum Therapeutics

This paper develops antiviral decoy particles using phase-separation scaffolds to inhibit coronavirus and influenza infections.

GelMetrics: An algorithm for analyzing the dynamics of gel-like phase separated condensates

GelMetrics quantifies dynamics of gel-like phase-separated condensates by tracking fluorescence over time, revealing biophysical properties and the impact of intrinsically disordered regions.

A cell-free assay for rapid screening of inhibitors of hACE2-receptor - SARS-CoV-2-Spike binding

The paper describes a cell-free assay using fluorescent particles and labeled hACE2 to screen inhibitors of SARS-CoV-2 Spike-hACE2 binding, demonstrating its effectiveness with known inhibitors and RNA-based trapping.

Overcoming the design, build, test (DBT) bottleneck for synthesis of nonrepetitive protein-RNA binding cassettes for RNA applications

The paper uses high-throughput oligo libraries and machine learning to design non-repetitive RNA binding cassettes for gene editing and RNA tracking, demonstrating their functionality in mammalian cells.

Demonstration of de novo chemotaxis in E. coli using a real-time, quantitative, and digital-like approach

The paper demonstrates a synthetic chemoreceptor in E. coli for histamine using computational design and a novel quantitative assay to characterize chemotaxis.