Synaptic imbalance and increased inhibition impair motor function in SMA
Emily V. Fletcher, Joshua I. Chalif, Travis M. Rotterman, John G. Pagiazitis, Meaghan Van Alstyne, Nandhini Sivakumar, Danny M. Florez-Paz, Joseph E. Rabinowitz, Livio Pellizzoni, Francisco J. Álvarez, George Z. Mentis
This study shows that unbalanced excitation-inhibition neurotransmission in SMA mice impairs motor function, and reducing inhibition improves neuronal function and behavior.
Science Advances · Sep 5, 2025Peer-reviewedNeuroscience