Meaghan Van Alstyne

Nuclear tau aggregates inhibit RNA export and form by secondary seeding from cytosolic tau aggregates.

Synaptic imbalance and increased inhibition impair motor function in SMA

This study shows that unbalanced excitation-inhibition neurotransmission in SMA mice impairs motor function, and reducing inhibition improves neuronal function and behavior.

A chemical screen identifies p38 MAPK inhibition as a candidate neuroprotective strategy for combinatorial SMA therapy

This study identifies p38 MAPK inhibition as a neuroprotective strategy that synergizes with SMN upregulation to improve motor function and survival in SMA mice.

Polyserine peptides are toxic and exacerbate tau pathology in mice

This study shows that polyserine peptides are toxic and worsen tau pathology in mice, supporting their role in human tauopathies.

Cytosolic condensates enriched in polyserine repeats are preferred sites of tau fiber propagation

The paper shows polyserine repeats in SRRM2 and PNN recruit to tau aggregates and promote tau fiber propagation in cytoplasmic condensates.

SMN controls neuromuscular junction integrity through U7 snRNP

This study identifies a role for SMN in maintaining neuromuscular junction integrity through U7 snRNP function in SMA mice.

Stasimon contributes to the loss of sensory synapses and motor neuron death in a mouse model of spinal muscular atrophy

This study shows that Stasimon overexpression in SMA mice improves motor function by preventing synaptic loss and motor neuron death through mechanisms involving p53 regulation.